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See More Important Safety Information. There are no available data in pregnant women to inform a drug associated risk. NEXAVAR is indicated for the treatment of patients with locally recurrent or metastatic, progressive, differentiated thyroid carcinoma (DTC) that is refractory to radioactive iodine treatment. Differentiated thyroid carcinoma. Patients at increased risk for ventricular arrhythmias. It is not known if Nexavar is safe and effective in children. Based on findings from animal studies and mechanism of action, therapy may cause fetal harm when administered to a pregnant woman; in animal reproduction studies, oral administration to pregnant rats and rabbits during period of organogenesis resulted in embryo-fetal toxicities at maternal. NEXAVAR®(sorafenib) is available by prescription through a network of specialty pharmacy providers (SPPs),* self-dispensing pharmacies, and outpatient pharmacies. Sorafenib is a targeted cancer drug and is also known by its brand name, Nexavar. Contents 1 Mechanism of action. The select network of SPPs offers support services such as: Getting new patients started on therapy Providing easy access to counselors Ensuring fast, reliable delivery of prescriptions. Warnings You should not use Nexavar if you have squamous cell lung cancer and you are being treated with carboplatin and paclitaxel. NEXAVAR is indicated for the treatment of patients with advanced renal cell carcinoma (RCC). : Sorafenib is approved to be used alone (as a single agent). : Targeted therapy (also referred to as a tyrosine kinase inhibitor or TKI). (For more detail, see "How Nexavar Works" below. Nexavar is used to treat liver cancer, thyroid cancer, or kidney cancer. Resources for Expert Assistance and Care Helpline (REACH) 866-NEXAVAR (866-639-2827) What type of drug is it? EP 255 is still valid until mid-2022, but the original patent for sorafenib has already expired.. Discontinue for unexplained transaminase elevations. Renal cell carcinoma Nexavar is indicated for the treatment of patients with advanced renal cell carcinoma who have failed prior interferon-alpha or interleukin-2 based therapy or are considered unsuitable for such therapy. • Drug-Induced Liver Injury: Monitor liver function tests regularly; NEXAVAR (sorafenib) tablets, for oral use. Sorafenib (rINN), marketed as Nexavar by Bayer, is a drug approved for the treatment of advanced renal cell carcinoma (primary kidney cancer). 2) See full prescribing information for NEXAVAR. Nexavar (sorafenib) is an oral multi-kinase inhibitor indicated for the treatment of hepatocellular carcinoma, renal cell carcinoma, and thyroid carcinoma. Nexavar is classified as a, tyrosine kinase inhibitor, angiogenesis inhibitor, VEGF inhibitor. Development timeline for Nexavar Further information Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances Pregnancy. Nexavar can cause heart problems Nexavar is indicated for the treatment of hepatocellular carcinoma. ) What Nexavar Is Used For: Treatment of advanced renal cell cancer Hepatocellular carcinoma (HCC) Thyroid cancer. NEXAVAR safely and effectively.

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